2022 head-to-head · Midsize Car
2022 Lexus LS vs Mercedes-Benz E-Class
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
The 2022 Mercedes-Benz E-Class is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,279 a year to fuel (26 MPG), versus $2,693 for the 2022 Lexus LS (22 MPG). That's roughly $414 a year, or about $2,072 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Lexus LS
- Mercedes-Benz E-Class
Side by side
| Lexus LS | Mercedes-Benz E-Class | |
|---|---|---|
| $2,693 | Your annual fuel cost | $2,279 |
| 22 MPG | Combined efficiency | 26 MPG |
| 18 MPG | City | 23 MPG |
| 29 MPG | Highway | 31 MPG |
| 99 cu ft | Passenger volume | 98 cu ft |
| 13 cu ft | Cargo volume | 13 cu ft |
| 404 g/mi | Tailpipe CO₂ (g/mi) | 342 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Gas | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 3.4L 6-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 10-speed automatic | Transmission | 9-speed automatic |
| RWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Lexus LS vs Mercedes-Benz E-Class across model years
- Lexus LS
- Mercedes-Benz E-Class
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Among 54 2022 midsize cars, the Lexus LS ranks 48th and the Mercedes-Benz E-Class 39th for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2022 Lexus LS or the 2022 Mercedes-Benz E-Class?
Measured by cost to drive, the Mercedes-Benz E-Class. The Lexus LS is rated 22 MPG combined and the Mercedes-Benz E-Class 26 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2022 Lexus LS vs. the Mercedes-Benz E-Class per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,693 for the Lexus LS and $2,279 for the Mercedes-Benz E-Class.
Lexus LS vs Mercedes-Benz E-Class in other years
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