2022 head-to-head · Midsize Car
2022 Lexus LS Hybrid vs Mercedes-Benz E-Class
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 3.5L 6-cyl · CVT · 25 MPG
The 2022 Mercedes-Benz E-Class is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,279 a year to fuel (26 MPG), versus $2,370 for the 2022 Lexus LS Hybrid (25 MPG). That's roughly $91 a year, or about $456 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Lexus LS Hybrid
- Mercedes-Benz E-Class
Side by side
| Lexus LS Hybrid | Mercedes-Benz E-Class | |
|---|---|---|
| $2,370 | Your annual fuel cost | $2,279 |
| 25 MPG | Combined efficiency | 26 MPG |
| 22 MPG | City | 23 MPG |
| 29 MPG | Highway | 31 MPG |
| 99 cu ft | Passenger volume | 98 cu ft |
| 12 cu ft | Cargo volume | 13 cu ft |
| 358 g/mi | Tailpipe CO₂ (g/mi) | 342 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Hybrid | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 3.5L 6-cyl | Engine / motor | 2.0L 4-cyl turbo |
| CVT | Transmission | 9-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Lexus LS Hybrid vs Mercedes-Benz E-Class across model years
- Lexus LS Hybrid
- Mercedes-Benz E-Class
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Mercedes-Benz E-Class has more cargo space (13 vs. 12 cu ft).
Among 54 2022 midsize cars, the Lexus LS Hybrid ranks 42nd and the Mercedes-Benz E-Class 39th for lowest fuel cost.
The powertrains differ: the Lexus LS Hybrid is a full hybrid, while the Mercedes-Benz E-Class is a conventional gas model.
Frequently asked questions
Which is more fuel-efficient, the 2022 Lexus LS Hybrid or the 2022 Mercedes-Benz E-Class?
Measured by cost to drive, the Mercedes-Benz E-Class. The Lexus LS Hybrid is rated 25 MPG combined and the Mercedes-Benz E-Class 26 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2022 Lexus LS Hybrid vs. the Mercedes-Benz E-Class per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,370 for the Lexus LS Hybrid and $2,279 for the Mercedes-Benz E-Class.
Which has more cargo space?
The Mercedes-Benz E-Class, with 13 cu ft of luggage volume versus 12 cu ft (EPA interior volume index).
Lexus LS Hybrid vs Mercedes-Benz E-Class in other years
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