2022 head-to-head · Midsize Car
2022 Cadillac CT5 vs Mercedes-Benz E-Class
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
The 2022 Cadillac CT5 is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,194 a year to fuel (27 MPG), versus $2,279 for the 2022 Mercedes-Benz E-Class (26 MPG). That's roughly $84 a year, or about $422 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Cadillac CT5
- Mercedes-Benz E-Class
Side by side
| Cadillac CT5 | Mercedes-Benz E-Class | |
|---|---|---|
| $2,194 | Your annual fuel cost | $2,279 |
| 27 MPG | Combined efficiency | 26 MPG |
| 23 MPG | City | 23 MPG |
| 33 MPG | Highway | 31 MPG |
| 99 cu ft | Passenger volume | 98 cu ft |
| 11 cu ft | Cargo volume | 13 cu ft |
| 333 g/mi | Tailpipe CO₂ (g/mi) | 342 g/mi |
| 6/10 | EPA fuel economy score | 5/10 |
| 6/10 | EPA greenhouse gas score | 5/10 |
| Gas | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 2.0L 4-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 10-speed automatic | Transmission | 9-speed automatic |
| RWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Cadillac CT5 vs Mercedes-Benz E-Class across model years
- Cadillac CT5
- Mercedes-Benz E-Class
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Mercedes-Benz E-Class has more cargo space (13 vs. 11 cu ft).
Among 54 2022 midsize cars, the Cadillac CT5 ranks 38th and the Mercedes-Benz E-Class 39th for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2022 Cadillac CT5 or the 2022 Mercedes-Benz E-Class?
Measured by cost to drive, the Cadillac CT5. The Cadillac CT5 is rated 27 MPG combined and the Mercedes-Benz E-Class 26 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2022 Cadillac CT5 vs. the Mercedes-Benz E-Class per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,194 for the Cadillac CT5 and $2,279 for the Mercedes-Benz E-Class.
Which has more cargo space?
The Mercedes-Benz E-Class, with 13 cu ft of luggage volume versus 11 cu ft (EPA interior volume index).
Cadillac CT5 vs Mercedes-Benz E-Class in other years
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