2022 head-to-head · Compact Car
2022 Audi S4 vs Mercedes-Benz CLS-Class Hybrid
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
4WD · 3.0L 6-cyl turbo · 8-speed automatic · 24 MPG
4WD · 3.0L 6-cyl turbo · 9-speed automatic · 25 MPG
The 2022 Mercedes-Benz CLS-Class Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,370 a year to fuel (25 MPG), versus $2,469 for the 2022 Audi S4 (24 MPG). That's roughly $99 a year, or about $494 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S4
- Mercedes-Benz CLS-Class Hybrid
Side by side
| Audi S4 | Mercedes-Benz CLS-Class Hybrid | |
|---|---|---|
| $2,469 | Your annual fuel cost | $2,370 |
| 24 MPG | Combined efficiency | 25 MPG |
| 21 MPG | City | 22 MPG |
| 30 MPG | Highway | 30 MPG |
| 92 cu ft | Passenger volume | 93 cu ft |
| 12 cu ft | Cargo volume | 12 cu ft |
| 363 g/mi | Tailpipe CO₂ (g/mi) | 357 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Gas | Powertrain | Hybrid |
| Premium gasoline | Fuel | Premium gasoline |
| 3.0L 6-cyl turbo | Engine / motor | 3.0L 6-cyl turbo |
| 8-speed automatic | Transmission | 9-speed automatic |
| 4WD | Drivetrain | 4WD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S4 vs Mercedes-Benz CLS-Class Hybrid across model years
- Audi S4
- Mercedes-Benz CLS-Class Hybrid
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Among 33 2022 compact cars, the Audi S4 ranks 30th and the Mercedes-Benz CLS-Class Hybrid 27th for lowest fuel cost.
The powertrains differ: the Audi S4 is a conventional gas model, while the Mercedes-Benz CLS-Class Hybrid is a full hybrid.
Frequently asked questions
Which is more fuel-efficient, the 2022 Audi S4 or the 2022 Mercedes-Benz CLS-Class Hybrid?
Measured by cost to drive, the Mercedes-Benz CLS-Class Hybrid. The Audi S4 is rated 24 MPG combined and the Mercedes-Benz CLS-Class Hybrid 25 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2022 Audi S4 vs. the Mercedes-Benz CLS-Class Hybrid per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,469 for the Audi S4 and $2,370 for the Mercedes-Benz CLS-Class Hybrid.
Audi S4 vs Mercedes-Benz CLS-Class Hybrid in other years
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