2019 head-to-head · Compact Car

2019 Audi S4 vs Mercedes-Benz CLS-Class Hybrid

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,469/ year to fuel
24 MPG

AWD · 3.0L 6-cyl turbo · 8-speed automatic · 24 MPG

✓ Cheaper to run
$2,279/ year to fuel
26 MPG

The 2019 Mercedes-Benz CLS-Class Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,279 a year to fuel (26 MPG), versus $2,469 for the 2019 Audi S4 (24 MPG). That's roughly $190 a year, or about $950 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Audi S4
  • Mercedes-Benz CLS-Class Hybrid

Side by side

Audi S4Mercedes-Benz CLS-Class Hybrid
$2,469 Your annual fuel cost $2,279
24 MPG Combined efficiency 26 MPG
21 MPG City 24 MPG
30 MPG Highway 31 MPG
90 cu ft Passenger volume 93 cu ft
13 cu ft Cargo volume 12 cu ft
371 g/mi Tailpipe CO₂ (g/mi) 334 g/mi
5/10 EPA fuel economy score 5/10
5/10 EPA greenhouse gas score 5/10
Gas Powertrain Hybrid
Premium gasoline Fuel Premium gasoline
3.0L 6-cyl turbo Engine / motor 3.0L 6-cyl turbo
8-speed automatic Transmission 9-speed automatic
AWD Drivetrain RWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Audi S4 vs Mercedes-Benz CLS-Class Hybrid across model years

  • Audi S4
  • Mercedes-Benz CLS-Class Hybrid

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Mercedes-Benz CLS-Class Hybrid has more passenger space (93 vs. 90 cu ft); the Audi S4 has more cargo space (13 vs. 12 cu ft).

Among 43 2019 compact cars, the Audi S4 ranks 37th and the Mercedes-Benz CLS-Class Hybrid 35th for lowest fuel cost.

The powertrains differ: the Audi S4 is a conventional gas model, while the Mercedes-Benz CLS-Class Hybrid is a full hybrid.

Frequently asked questions

Which is more fuel-efficient, the 2019 Audi S4 or the 2019 Mercedes-Benz CLS-Class Hybrid?

Measured by cost to drive, the Mercedes-Benz CLS-Class Hybrid. The Audi S4 is rated 24 MPG combined and the Mercedes-Benz CLS-Class Hybrid 26 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2019 Audi S4 vs. the Mercedes-Benz CLS-Class Hybrid per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,469 for the Audi S4 and $2,279 for the Mercedes-Benz CLS-Class Hybrid.

Which has more cargo space?

The Audi S4, with 13 cu ft of luggage volume versus 12 cu ft (EPA interior volume index).

Audi S4 vs Mercedes-Benz CLS-Class Hybrid in other years

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