2022 head-to-head · Compact Car

2022 Cadillac CT4 vs Mercedes-Benz CLS-Class Hybrid

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,194/ year to fuel
27 MPG
✓ Cheaper to run
$2,370/ year to fuel
25 MPG

4WD · 3.0L 6-cyl turbo · 9-speed automatic · 25 MPG

The 2022 Cadillac CT4 is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,194 a year to fuel (27 MPG), versus $2,370 for the 2022 Mercedes-Benz CLS-Class Hybrid (25 MPG). That's roughly $176 a year, or about $878 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Cadillac CT4
  • Mercedes-Benz CLS-Class Hybrid

Side by side

Cadillac CT4Mercedes-Benz CLS-Class Hybrid
$2,194 Your annual fuel cost $2,370
27 MPG Combined efficiency 25 MPG
23 MPG City 22 MPG
34 MPG Highway 30 MPG
90 cu ft Passenger volume 93 cu ft
11 cu ft Cargo volume 12 cu ft
331 g/mi Tailpipe CO₂ (g/mi) 357 g/mi
6/10 EPA fuel economy score 5/10
6/10 EPA greenhouse gas score 5/10
Gas Powertrain Hybrid
Premium gasoline Fuel Premium gasoline
2.0L 4-cyl turbo Engine / motor 3.0L 6-cyl turbo
8-speed automatic Transmission 9-speed automatic
RWD Drivetrain 4WD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Cadillac CT4 vs Mercedes-Benz CLS-Class Hybrid across model years

  • Cadillac CT4
  • Mercedes-Benz CLS-Class Hybrid

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Mercedes-Benz CLS-Class Hybrid has more passenger space (93 vs. 90 cu ft); the Mercedes-Benz CLS-Class Hybrid has more cargo space (12 vs. 11 cu ft).

Among 33 2022 compact cars, the Cadillac CT4 ranks 24th and the Mercedes-Benz CLS-Class Hybrid 27th for lowest fuel cost.

The powertrains differ: the Cadillac CT4 is a conventional gas model, while the Mercedes-Benz CLS-Class Hybrid is a full hybrid.

Frequently asked questions

Which is more fuel-efficient, the 2022 Cadillac CT4 or the 2022 Mercedes-Benz CLS-Class Hybrid?

Measured by cost to drive, the Cadillac CT4. The Cadillac CT4 is rated 27 MPG combined and the Mercedes-Benz CLS-Class Hybrid 25 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2022 Cadillac CT4 vs. the Mercedes-Benz CLS-Class Hybrid per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,194 for the Cadillac CT4 and $2,370 for the Mercedes-Benz CLS-Class Hybrid.

Which has more cargo space?

The Mercedes-Benz CLS-Class Hybrid, with 12 cu ft of luggage volume versus 11 cu ft (EPA interior volume index).

Cadillac CT4 vs Mercedes-Benz CLS-Class Hybrid in other years

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