2021 head-to-head · Compact Car

2021 Acura TLX vs Audi S4

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,370/ year to fuel
25 MPG
✓ Cheaper to run
$2,576/ year to fuel
23 MPG

AWD · 3.0L 6-cyl turbo · 8-speed automatic · 23 MPG

The 2021 Acura TLX is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,370 a year to fuel (25 MPG), versus $2,576 for the 2021 Audi S4 (23 MPG). That's roughly $206 a year, or about $1,030 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Acura TLX
  • Audi S4

Side by side

Acura TLXAudi S4
$2,370 Your annual fuel cost $2,576
25 MPG Combined efficiency 23 MPG
22 MPG City 20 MPG
30 MPG Highway 28 MPG
93 cu ft Passenger volume 92 cu ft
14 cu ft Cargo volume 12 cu ft
357 g/mi Tailpipe CO₂ (g/mi) 380 g/mi
5/10 EPA fuel economy score 5/10
5/10 EPA greenhouse gas score 5/10
Gas Powertrain Gas
Premium gasoline Fuel Premium gasoline
2.0L 4-cyl turbo Engine / motor 3.0L 6-cyl turbo
10-speed automatic Transmission 8-speed automatic
FWD Drivetrain AWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Acura TLX vs Audi S4 across model years

  • Acura TLX
  • Audi S4

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Acura TLX has more cargo space (14 vs. 12 cu ft).

Among 37 2021 compact cars, the Acura TLX ranks 30th and the Audi S4 32nd for lowest fuel cost.

Frequently asked questions

Which is more fuel-efficient, the 2021 Acura TLX or the 2021 Audi S4?

Measured by cost to drive, the Acura TLX. The Acura TLX is rated 25 MPG combined and the Audi S4 23 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2021 Acura TLX vs. the Audi S4 per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,370 for the Acura TLX and $2,576 for the Audi S4.

Which has more cargo space?

The Acura TLX, with 14 cu ft of luggage volume versus 12 cu ft (EPA interior volume index).

Acura TLX vs Audi S4 in other years

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