2026 head-to-head · Midsize Car

2026 Cadillac CT5 vs Lexus LS

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,279/ year to fuel
26 MPG
✓ Cheaper to run
$2,821/ year to fuel
21 MPG

AWD · 3.4L 6-cyl turbo · 10-speed automatic · 21 MPG

The 2026 Cadillac CT5 is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,279 a year to fuel (26 MPG), versus $2,821 for the 2026 Lexus LS (21 MPG). That's roughly $543 a year, or about $2,713 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Cadillac CT5
  • Lexus LS

Side by side

Cadillac CT5Lexus LS
$2,279 Your annual fuel cost $2,821
26 MPG Combined efficiency 21 MPG
22 MPG City 17 MPG
31 MPG Highway 27 MPG
99 cu ft Passenger volume 99 cu ft
11 cu ft Cargo volume 13 cu ft
346 g/mi Tailpipe CO₂ (g/mi) 434 g/mi
5/10 EPA fuel economy score 4/10
5/10 EPA greenhouse gas score 4/10
Gas Powertrain Gas
Premium gasoline Fuel Premium gasoline
2.0L 4-cyl turbo Engine / motor 3.4L 6-cyl turbo
10-speed automatic Transmission 10-speed automatic
RWD Drivetrain AWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Cadillac CT5 vs Lexus LS across model years

  • Cadillac CT5
  • Lexus LS

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Lexus LS has more cargo space (13 vs. 11 cu ft).

Among 31 2026 midsize cars, the Cadillac CT5 ranks 25th and the Lexus LS 30th for lowest fuel cost.

Frequently asked questions

Which is more fuel-efficient, the 2026 Cadillac CT5 or the 2026 Lexus LS?

Measured by cost to drive, the Cadillac CT5. The Cadillac CT5 is rated 26 MPG combined and the Lexus LS 21 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2026 Cadillac CT5 vs. the Lexus LS per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,279 for the Cadillac CT5 and $2,821 for the Lexus LS.

Which has more cargo space?

The Lexus LS, with 13 cu ft of luggage volume versus 11 cu ft (EPA interior volume index).

Cadillac CT5 vs Lexus LS in other years

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