2026 head-to-head · Midsize Car
2026 Audi S5 vs Mercedes-Benz E-Class Hybrid
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 3.0L 6-cyl turbo · 7-speed dual-clutch · 23 MPG
The 2026 Mercedes-Benz E-Class Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,116 a year to fuel (28 MPG), versus $2,576 for the 2026 Audi S5 (23 MPG). That's roughly $460 a year, or about $2,300 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S5
- Mercedes-Benz E-Class Hybrid
Side by side
| Audi S5 | Mercedes-Benz E-Class Hybrid | |
|---|---|---|
| $2,576 | Your annual fuel cost | $2,116 |
| 23 MPG | Combined efficiency | 28 MPG |
| 20 MPG | City | 25 MPG |
| 29 MPG | Highway | 33 MPG |
| 91 cu ft | Passenger volume | 100 cu ft |
| 22 cu ft | Cargo volume | 13 cu ft |
| 386 g/mi | Tailpipe CO₂ (g/mi) | 316 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Gas | Powertrain | Hybrid |
| Premium gasoline | Fuel | Premium gasoline |
| 3.0L 6-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 7-speed dual-clutch | Transmission | 9-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S5 vs Mercedes-Benz E-Class Hybrid across model years
- Audi S5
- Mercedes-Benz E-Class Hybrid
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Mercedes-Benz E-Class Hybrid has more passenger space (100 vs. 91 cu ft); the Audi S5 has more cargo space (22 vs. 13 cu ft).
Among 31 2026 midsize cars, the Audi S5 ranks 27th and the Mercedes-Benz E-Class Hybrid 20th for lowest fuel cost.
The powertrains differ: the Audi S5 is a conventional gas model, while the Mercedes-Benz E-Class Hybrid is a full hybrid.
Frequently asked questions
Which is more fuel-efficient, the 2026 Audi S5 or the 2026 Mercedes-Benz E-Class Hybrid?
Measured by cost to drive, the Mercedes-Benz E-Class Hybrid. The Audi S5 is rated 23 MPG combined and the Mercedes-Benz E-Class Hybrid 28 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2026 Audi S5 vs. the Mercedes-Benz E-Class Hybrid per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,576 for the Audi S5 and $2,116 for the Mercedes-Benz E-Class Hybrid.
Which has more cargo space?
The Audi S5, with 22 cu ft of luggage volume versus 13 cu ft (EPA interior volume index).
Audi S5 vs Mercedes-Benz E-Class Hybrid in other years
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