2020 head-to-head · Subcompact Car

2020 Audi S5 vs Mercedes-Benz E-Class Hybrid

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,576/ year to fuel
23 MPG
✓ Cheaper to run
$2,469/ year to fuel
24 MPG

The 2020 Mercedes-Benz E-Class Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,469 a year to fuel (24 MPG), versus $2,576 for the 2020 Audi S5 (23 MPG). That's roughly $107 a year, or about $537 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Audi S5
  • Mercedes-Benz E-Class Hybrid

Side by side

Audi S5Mercedes-Benz E-Class Hybrid
$2,576 Your annual fuel cost $2,469
23 MPG Combined efficiency 24 MPG
20 MPG City 21 MPG
27 MPG Highway 28 MPG
84 cu ft Passenger volume 97 cu ft
13 cu ft Cargo volume 13 cu ft
393 g/mi Tailpipe CO₂ (g/mi) 370 g/mi
5/10 EPA fuel economy score 5/10
5/10 EPA greenhouse gas score 5/10
Gas Powertrain Hybrid
Premium gasoline Fuel Premium gasoline
3.0L 6-cyl turbo Engine / motor 3.0L 6-cyl
8-speed automatic Transmission 9-speed automatic
AWD Drivetrain 4WD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Audi S5 vs Mercedes-Benz E-Class Hybrid across model years

  • Audi S5
  • Mercedes-Benz E-Class Hybrid

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Mercedes-Benz E-Class Hybrid has more passenger space (97 vs. 84 cu ft).

Among 39 2020 subcompact cars, the Audi S5 ranks 25th and the Mercedes-Benz E-Class Hybrid 23rd for lowest fuel cost.

The powertrains differ: the Audi S5 is a conventional gas model, while the Mercedes-Benz E-Class Hybrid is a full hybrid.

Frequently asked questions

Which is more fuel-efficient, the 2020 Audi S5 or the 2020 Mercedes-Benz E-Class Hybrid?

Measured by cost to drive, the Mercedes-Benz E-Class Hybrid. The Audi S5 is rated 23 MPG combined and the Mercedes-Benz E-Class Hybrid 24 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2020 Audi S5 vs. the Mercedes-Benz E-Class Hybrid per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,576 for the Audi S5 and $2,469 for the Mercedes-Benz E-Class Hybrid.

Audi S5 vs Mercedes-Benz E-Class Hybrid in other years

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