2025 head-to-head · Midsize Car
2025 Audi A5 Hybrid vs Mercedes-Benz E-Class Hybrid
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
The 2025 Audi A5 Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,043 a year to fuel (29 MPG), versus $2,116 for the 2025 Mercedes-Benz E-Class Hybrid (28 MPG). That's roughly $73 a year, or about $365 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi A5 Hybrid
- Mercedes-Benz E-Class Hybrid
Side by side
| Audi A5 Hybrid | Mercedes-Benz E-Class Hybrid | |
|---|---|---|
| $2,043 | Your annual fuel cost | $2,116 |
| 29 MPG | Combined efficiency | 28 MPG |
| 26 MPG | City | 25 MPG |
| 36 MPG | Highway | 33 MPG |
| 91 cu ft | Passenger volume | 100 cu ft |
| 22 cu ft | Cargo volume | 13 cu ft |
| 301 g/mi | Tailpipe CO₂ (g/mi) | 316 g/mi |
| 6/10 | EPA fuel economy score | 6/10 |
| 6/10 | EPA greenhouse gas score | 6/10 |
| Hybrid | Powertrain | Hybrid |
| Premium gasoline | Fuel | Premium gasoline |
| 2.0L 4-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 7-speed dual-clutch | Transmission | 9-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi A5 Hybrid vs Mercedes-Benz E-Class Hybrid across model years
- Audi A5 Hybrid
- Mercedes-Benz E-Class Hybrid
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Mercedes-Benz E-Class Hybrid has more passenger space (100 vs. 91 cu ft); the Audi A5 Hybrid has more cargo space (22 vs. 13 cu ft).
Among 42 2025 midsize cars, the Audi A5 Hybrid ranks 25th and the Mercedes-Benz E-Class Hybrid 26th for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2025 Audi A5 Hybrid or the 2025 Mercedes-Benz E-Class Hybrid?
Measured by cost to drive, the Audi A5 Hybrid. The Audi A5 Hybrid is rated 29 MPG combined and the Mercedes-Benz E-Class Hybrid 28 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2025 Audi A5 Hybrid vs. the Mercedes-Benz E-Class Hybrid per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,043 for the Audi A5 Hybrid and $2,116 for the Mercedes-Benz E-Class Hybrid.
Which has more cargo space?
The Audi A5 Hybrid, with 22 cu ft of luggage volume versus 13 cu ft (EPA interior volume index).
Audi A5 Hybrid vs Mercedes-Benz E-Class Hybrid in other years
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