2022 head-to-head · Large Car

2022 Mercedes-Benz S-Class vs Mercedes-Benz S-Class Hybrid

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$3,950/ year to fuel
15 MPG

AWD · 6.0L 12-cyl turbo · 9-speed automatic · 15 MPG

✓ Cheaper to run
$2,469/ year to fuel
24 MPG

The 2022 Mercedes-Benz S-Class Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,469 a year to fuel (24 MPG), versus $3,950 for the 2022 Mercedes-Benz S-Class (15 MPG). That's roughly $1,481 a year, or about $7,406 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Mercedes-Benz S-Class
  • Mercedes-Benz S-Class Hybrid

Side by side

Mercedes-Benz S-ClassMercedes-Benz S-Class Hybrid
$3,950 Your annual fuel cost $2,469
15 MPG Combined efficiency 24 MPG
12 MPG City 21 MPG
21 MPG Highway 30 MPG
118 cu ft Passenger volume 112 cu ft
13 cu ft Cargo volume 13 cu ft
599 g/mi Tailpipe CO₂ (g/mi) 372 g/mi
2/10 EPA fuel economy score 5/10
2/10 EPA greenhouse gas score 5/10
Gas Powertrain Hybrid
Premium gasoline Fuel Premium gasoline
6.0L 12-cyl turbo Engine / motor 3.0L 6-cyl
9-speed automatic Transmission 9-speed automatic
AWD Drivetrain AWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Mercedes-Benz S-Class vs Mercedes-Benz S-Class Hybrid across model years

  • Mercedes-Benz S-Class
  • Mercedes-Benz S-Class Hybrid

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Mercedes-Benz S-Class has more passenger space (118 vs. 112 cu ft).

Among 29 2022 large cars, the Mercedes-Benz S-Class ranks 27th and the Mercedes-Benz S-Class Hybrid 21st for lowest fuel cost.

The powertrains differ: the Mercedes-Benz S-Class is a conventional gas model, while the Mercedes-Benz S-Class Hybrid is a full hybrid.

Frequently asked questions

Which is more fuel-efficient, the 2022 Mercedes-Benz S-Class or the 2022 Mercedes-Benz S-Class Hybrid?

Measured by cost to drive, the Mercedes-Benz S-Class Hybrid. The Mercedes-Benz S-Class is rated 15 MPG combined and the Mercedes-Benz S-Class Hybrid 24 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2022 Mercedes-Benz S-Class vs. the Mercedes-Benz S-Class Hybrid per year?

At 15,000 miles a year with $3.95/gal premium gas, about $3,950 for the Mercedes-Benz S-Class and $2,469 for the Mercedes-Benz S-Class Hybrid.

Mercedes-Benz S-Class vs Mercedes-Benz S-Class Hybrid in other years

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