2021 head-to-head · Midsize Car
2021 Audi S6 Hybrid vs Mercedes-Benz E-Class
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 2.9L 6-cyl turbo · 8-speed automatic · 22 MPG
The 2021 Mercedes-Benz E-Class is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,370 a year to fuel (25 MPG), versus $2,693 for the 2021 Audi S6 Hybrid (22 MPG). That's roughly $323 a year, or about $1,616 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S6 Hybrid
- Mercedes-Benz E-Class
Side by side
| Audi S6 Hybrid | Mercedes-Benz E-Class | |
|---|---|---|
| $2,693 | Your annual fuel cost | $2,370 |
| 22 MPG | Combined efficiency | 25 MPG |
| 18 MPG | City | 22 MPG |
| 28 MPG | Highway | 31 MPG |
| 98 cu ft | Passenger volume | 98 cu ft |
| 16 cu ft | Cargo volume | 13 cu ft |
| 410 g/mi | Tailpipe CO₂ (g/mi) | 349 g/mi |
| 4/10 | EPA fuel economy score | 5/10 |
| 4/10 | EPA greenhouse gas score | 5/10 |
| Hybrid | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 2.9L 6-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 8-speed automatic | Transmission | 9-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S6 Hybrid vs Mercedes-Benz E-Class across model years
- Audi S6 Hybrid
- Mercedes-Benz E-Class
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Audi S6 Hybrid has more cargo space (16 vs. 13 cu ft).
Among 54 2021 midsize cars, the Audi S6 Hybrid ranks 47th and the Mercedes-Benz E-Class 40th for lowest fuel cost.
The powertrains differ: the Audi S6 Hybrid is a full hybrid, while the Mercedes-Benz E-Class is a conventional gas model.
Frequently asked questions
Which is more fuel-efficient, the 2021 Audi S6 Hybrid or the 2021 Mercedes-Benz E-Class?
Measured by cost to drive, the Mercedes-Benz E-Class. The Audi S6 Hybrid is rated 22 MPG combined and the Mercedes-Benz E-Class 25 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2021 Audi S6 Hybrid vs. the Mercedes-Benz E-Class per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,693 for the Audi S6 Hybrid and $2,370 for the Mercedes-Benz E-Class.
Which has more cargo space?
The Audi S6 Hybrid, with 16 cu ft of luggage volume versus 13 cu ft (EPA interior volume index).
Audi S6 Hybrid vs Mercedes-Benz E-Class in other years
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