2016 head-to-head · Midsize Car
2016 Audi S6 vs Mercedes-Benz E-Class
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 4.0L 8-cyl turbo · 7-speed dual-clutch · 21 MPG
The 2016 Mercedes-Benz E-Class is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,576 a year to fuel (23 MPG), versus $2,821 for the 2016 Audi S6 (21 MPG). That's roughly $245 a year, or about $1,227 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S6
- Mercedes-Benz E-Class
Side by side
| Audi S6 | Mercedes-Benz E-Class | |
|---|---|---|
| $2,821 | Your annual fuel cost | $2,576 |
| 21 MPG | Combined efficiency | 23 MPG |
| 18 MPG | City | 20 MPG |
| 27 MPG | Highway | 29 MPG |
| 98 cu ft | Passenger volume | 81 cu ft |
| 16 cu ft | Cargo volume | 11 cu ft |
| 423 g/mi | Tailpipe CO₂ (g/mi) | 377 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Gas | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 4.0L 8-cyl turbo | Engine / motor | 3.0L 6-cyl turbo |
| 7-speed dual-clutch | Transmission | 7-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S6 vs Mercedes-Benz E-Class across model years
- Audi S6
- Mercedes-Benz E-Class
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Audi S6 has more passenger space (98 vs. 81 cu ft); the Audi S6 has more cargo space (16 vs. 11 cu ft).
Among 67 2016 midsize cars, the Audi S6 ranks 56th and the Mercedes-Benz E-Class 53rd for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2016 Audi S6 or the 2016 Mercedes-Benz E-Class?
Measured by cost to drive, the Mercedes-Benz E-Class. The Audi S6 is rated 21 MPG combined and the Mercedes-Benz E-Class 23 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2016 Audi S6 vs. the Mercedes-Benz E-Class per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,821 for the Audi S6 and $2,576 for the Mercedes-Benz E-Class.
Which has more cargo space?
The Audi S6, with 16 cu ft of luggage volume versus 11 cu ft (EPA interior volume index).
Audi S6 vs Mercedes-Benz E-Class in other years
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