2025 head-to-head · Compact Car
2025 Audi S4 vs Mercedes-Benz C-Class Hybrid
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 3.0L 6-cyl turbo · 8-speed automatic · 24 MPG
The 2025 Mercedes-Benz C-Class Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,043 a year to fuel (29 MPG), versus $2,469 for the 2025 Audi S4 (24 MPG). That's roughly $426 a year, or about $2,128 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S4
- Mercedes-Benz C-Class Hybrid
Side by side
| Audi S4 | Mercedes-Benz C-Class Hybrid | |
|---|---|---|
| $2,469 | Your annual fuel cost | $2,043 |
| 24 MPG | Combined efficiency | 29 MPG |
| 20 MPG | City | 25 MPG |
| 29 MPG | Highway | 35 MPG |
| 92 cu ft | Passenger volume | 93 cu ft |
| 12 cu ft | Cargo volume | 12 cu ft |
| 377 g/mi | Tailpipe CO₂ (g/mi) | 303 g/mi |
| 5/10 | EPA fuel economy score | 6/10 |
| 5/10 | EPA greenhouse gas score | 6/10 |
| Gas | Powertrain | Hybrid |
| Premium gasoline | Fuel | Premium gasoline |
| 3.0L 6-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 8-speed automatic | Transmission | 9-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S4 vs Mercedes-Benz C-Class Hybrid across model years
- Audi S4
- Mercedes-Benz C-Class Hybrid
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Among 26 2025 compact cars, the Audi S4 ranks 21st and the Mercedes-Benz C-Class Hybrid 16th for lowest fuel cost.
The powertrains differ: the Audi S4 is a conventional gas model, while the Mercedes-Benz C-Class Hybrid is a full hybrid.
Frequently asked questions
Which is more fuel-efficient, the 2025 Audi S4 or the 2025 Mercedes-Benz C-Class Hybrid?
Measured by cost to drive, the Mercedes-Benz C-Class Hybrid. The Audi S4 is rated 24 MPG combined and the Mercedes-Benz C-Class Hybrid 29 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2025 Audi S4 vs. the Mercedes-Benz C-Class Hybrid per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,469 for the Audi S4 and $2,043 for the Mercedes-Benz C-Class Hybrid.
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